Long-term potentiation at hippocampal perforant path-dentate astrocyte synapses
نویسندگان
چکیده
منابع مشابه
Effects of parental morphine addiction on long term potentiation of the perforant path to dentate gyrus in rat offsprings
Background: Evidences show that parental morphine addiction impairs CNS development, learning and memory in offsprings. Since long term potentiation (LTP) is a cellular mechanism of learning and memory, in this study the effect of parental morphine addiction on LTP induction in dentate gyrus by high frequency stimulation of perforant path was assessed. Materials and methods: In this experiment...
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The expression of homosynaptic long-term depression (LTD) is thought to mediate a crucial role in sustaining memory function. Our in vivo investigations of LTD expression at lateral (LPP) and medial perforant path (MPP) synapses in the dentate gyrus (DG) corroborate prior demonstrations that PP-DG LTD is difficult to induce in intact animals. In freely moving animals, LTD expression occurred in...
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The perforant path constitutes the primary projection system relaying information from the neocortex to the hippocampal formation. Long-term synaptic potentiation (LTP) in the perforant path projections to the dentate gyrus is well characterized. However, surprisingly few studies have addressed the mechanisms underlying LTP induction in the direct perforant path projections to the hippocampus. ...
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An approach combining signal detection theory and precise 3D reconstructions from serial section electron microscopy (3DEM) was used to investigate synaptic plasticity and information storage capacity at medial perforant path synapses in adult hippocampal dentate gyrus in vivo. Induction of long-term potentiation (LTP) markedly increased the frequencies of both small and large spines measured 3...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2009
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.04.005